BIGG

New WHO guidelines for treatment of gambiense human African trypanosomiasis including fexinidazole: substantial changes for clinical practice

Lindner, Andreas K; Lejon, Veerle; Chappuis, François; Seixas, Jorge; Kazumba, Leon; Barrett, Michael P; Mwamba, Erick; Erphas, Olema; Akl, Elie A; Villanueva, Gemma; Bergman, Hanna; Simarro, Pere; Ebeja, Augustin Kadima; Priotto, Gerardo; Franco, Jose Ramon.

Lancet infect. dis; 20 (2), 2020

Human African trypanosomiasis caused by Trypanosoma brucei gambiense is a parasitic infection that usually progresses to coma and death unless treated. WHO has updated its guidelines for the treatment of this infection on the basis of independent literature reviews and using the Grading of Recommendation...

Tripanosomiasis Africana/tratamiento farmacológico, Trypanosoma brucei gambiense, Pentamidina/administración & dosificación, Nifurtimox/administración & dosificación, Nitroimidazoles/administración & dosificación, Líquido Cefalorraquídeo/parasitología, Quimioterapia Combinada, Tripanocidas/administración & dosificación, Eflornitina/administración & dosificación, Tripanosomiasis Africana/parasitología

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The use of delamanid in the treatment of multidrug-resistant tuberculosis: interim policy guidance

The aim of this guidance is to provide the interim principles that should guide the use of delamanid in conjunction with WHO-recommended MDR-TB treatment. It also specifies the essential treatment and management conditions for use of this drug, in particular the patient's eligibility criteria and safety ...